OpenSecrets' profile indicates that Priceline engaged in lobbying activities during 2022, as evidenced by the detailed data on expenditures and firm involvement. This event highlights the company's active role in influencing federal policy through targeted political contributions and lobbying efforts.

A hotel industry lobbying campaign has singled out Norwalk-based Priceline, among others, to spotlight its strong influence over industry policies. The campaign intends to draw attention to the political leverage wielded by Priceline and similar companies.

On May 9, 2023, Priceline faced significant customer backlash after stores displayed and distributed political flyers that criticized the Albanese Labor Government's 60-day dispensing policy. The flyers, allegedly authorized by the Pharmacy Guild of Australia, included claims that the government’s policy would lead to prescription medicine shortages. The move has spurred boycott threats and widespread criticism from customers and advocacy groups, raising concerns about the company’s use of its retail space for politically charged messaging.