Robert F. Kennedy Human Rights reiterated its commitment to upholding human rights and social justice through a statement that emphasizes its nonpartisan stance and clarifies its independence from political affiliations, notably distancing itself from Robert F. Kennedy Jr. This reaffirmation underscores the organization's dedication to democratic values and principled advocacy.

In an August 2024 report titled 'Inside the Black Hole', RFK Human Rights documented systemic human rights abuses at ICE detention centers in Louisiana. The report highlights deplorable living conditions, lack of legal access, and neglect, underscoring the challenges faced by detained immigrant students under policies associated with the Trump administration.

RFK Human Rights, alongside various civil society organizations and independent experts, issued a joint open letter urging states to impose an immediate moratorium on the sale, transfer, and use of surveillance technology in response to revelations about NSO Group’s spyware and its role in human rights abuses.

In July 2023, RFK Human Rights submitted petitions to the Working Group on Arbitrary Detention at the United Nations, advocating on behalf of human rights activists detained by repressive regimes in retaliation for exercising freedom of opinion and expression.

RFK Human Rights, in collaboration with The Associated Press-NORC Center for Public Affairs Research, conducted a survey revealing deep public concerns over escalating threats to press freedom, journalistic attacks, and misinformation. The survey was released ahead of World Press Freedom Day and underscores a commitment to safeguarding democratic values and protecting marginalized voices.

RFK Human Rights, through its Compass Investor Program, has joined forces with investors managing $1 trillion in AUM to pressure Wendy's into joining the Coalition of Immokalee Workers’ Fair Food Program (FFP). This worker-driven initiative aims to replace voluntary corporate social responsibility programs with legally binding agreements and rigorous worker-led monitoring to better protect farmworkers—predominantly from marginalized communities—in the wake of COVID-19.

On June 22, 2016, Robert F. Kennedy Human Rights co-hosted a briefing with the Tahrir Institute for Middle East Policy at the Dirksen Senate Office Building. The event highlighted Egypt's intensified crackdown on civil society and human rights, featuring speakers who condemned oppressive government actions and called for a calibrated U.S. policy response linked to human rights conditions.