During a Washington, D.C. gathering co-organized with the Jewish Federations of North America, the Conference of Presidents of Major American Jewish Organizations joined hundreds of leaders in calling for enhanced federal protection. This advocacy led to the allocation of approximately $94 million by DHS to bolster security measures amid a surge in antisemitic violence.

Former leaders of major U.S. Jewish advocacy groups criticized establishment organizations, including the Conference of Presidents, for remaining silent on Trump's crackdown on free speech and democratic norms.

On August 2, 2023, The Workers Circle resigned from the Conference of Presidents of Major American Jewish Organizations due to the organization's reluctance to critique Israel's policies and its failure to condemn anti-democratic actions such as voter suppression and gerrymandering in the United States. The resignation reflects concerns over the COP's lack of proactive engagement in defending democratic values.

The Conference of Presidents of Major American Jewish Organizations issued press releases endorsing U.S. defensive action against the Iranian nuclear threat and supporting Israel’s defensive measures, while urging the public to donate in support of these initiatives.

The Conference of Presidents of Major American Jewish Organizations arranged an off‐the‐record briefing featuring Reza Pahlavi, the would-be monarch of Iran, whose invitation has drawn criticism from within the community over his whitewashed portrayal of a repressive past. The event, set against the backdrop of the group’s previous support for the Trump administration's abandonment of the Iran nuclear deal, raises concerns about the legitimization of controversial regime change rhetoric.