The American Humane Society certified a 2,000-acre ecological preserve in Texas used by Colossal Biosciences for its de‑extinction projects involving cloned red wolves, underscoring its commitment to high animal welfare standards and ethical oversight.

A consumer protection complaint alleges that American Humane Society is misleading consumers by endorsing Foster Farms chicken products under its humane certification program, despite documented evidence of severe animal mistreatment in Foster Farms' supply chain.

A complaint alleges that American Humane Society misleads consumers by promoting Foster Farms products as animal-friendly while ignoring documented cases of severe animal abuse and neglect. This deceptive trade practice raises concerns about the organization's ethical responsibility in business practices.

American Humane Society has called on political campaigns to incorporate comprehensive animal welfare policies into their platforms, arguing that the treatment of animals is intrinsically linked to broader societal issues including public health, economic stability, and ethical governance. The organization’s initiative is aimed at encouraging political leaders to embrace humane values and to rectify long-standing neglect in animal policy, thereby promoting more compassionate and ethically grounded public policy.

On July 31, 2018, the Humane Society Legislative Fund endorsed Darren Soto in the Democratic Primary for Florida’s 9th Congressional District, reflecting strong political engagement and a commitment to progressive animal welfare and social justice measures. This endorsement aligns with a broader anti-fascist agenda by supporting candidates who advocate for humane and inclusive policies.