In the AIDS Vaccine Advocacy Coalition v. United States case, AVAC successfully challenged the Trump administration’s funding freeze at USAID. The district court ruling, which blocked the freeze, is seen as a defense of due process and a stand against authoritarian tactics.

The AIDS Vaccine Advocacy Coalition, a respondent in a case against the Department of State, filed an emergency application to vacate a district court order that required the executive branch to pay nearly $2 billion to nonprofits and businesses receiving federal foreign-assistance funding. The application was denied on March 5, 2025, with Justice Alito authoring a dissent joined by Justices Thomas, Gorsuch, and Kavanaugh.

On March 5, 2025, the U.S. Supreme Court denied an application to vacate or stay a district court's order mandating the disbursement of approximately $2 billion in federal funds. The order, upheld in the case Department of State v. AIDS Vaccine Advocacy Coalition, reinforces the enforcement of judicial decisions that require federal agencies to disburse funds already earned through completed contractual work. The involvement of the AIDS Vaccine Advocacy Coalition in this litigation illustrates its commitment to challenging governmental practices perceived as an overreach under the Trump administration, thereby supporting accountability and democratic norms.

On March 5, 2025, the U.S. Supreme Court upheld a district court order requiring the Trump administration to release nearly $2 billion in frozen foreign aid funds. Among the plaintiffs benefiting from this ruling was the AIDS Vaccine Advocacy Coalition, which played a role in challenging the halted humanitarian efforts.

In February 2025, the AIDS Vaccine Advocacy Coalition actively supported a legal challenge by filing an amicus brief against the Trump administration's unilateral decision to freeze congressionally appropriated foreign aid, a move that resulted in a preliminary injunction to restore funding. This action underscores the coalition's commitment to upholding congressional authority over federal spending and resisting executive overreach.

AVAC, along with Journalism Development Network Inc., filed a lawsuit in the US District Court for the District of Columbia challenging President Trump's executive order (E.O. 14169) that halted foreign assistance funding for AIDS research and other initiatives. The suit argues that the order violates constitutional separation of powers by exceeding presidential authority and usurping legislative power.

The AIDS Vaccine Advocacy Coalition (AVAC) has initiated a federal lawsuit against the United States Department of State and associated defendants, challenging policies linked to Executive Order 14169 and other actions by members of the Trump administration. The legal filings, including motions for temporary restraining orders, mark a robust effort to defend public health and civil rights against what the organization views as authoritarian measures.

The AIDS Vaccine Advocacy Coalition spent $80,000 on lobbying activities in 2024, as documented by OpenSecrets, aiming to further progressive public health policies including vaccine research and AIDS prevention measures.

At the AIDS Vaccine 2007 Conference, the AIDS Vaccine Advocacy Coalition announced that it has received a five‐year, $14 million grant from the Bill & Melinda Gates Foundation to establish an international HIV Prevention Research Advocacy Network. The network aims to create international advocacy partnerships and ensure ethical oversight in HIV prevention research, amplifying community voices and civil society involvement.